Human 5-HT1A receptor C(−1019)G polymorphism and psychopathology
نویسندگان
چکیده
منابع مشابه
Existence of Brain 5-HT1A–5-HT2A Isoreceptor Complexes with Antagonistic Allosteric Receptor–Receptor Interactions Regulating 5-HT1A Receptor Recognition
Studies on serotonin-selective reuptake inhibitors have established that disturbances in the ascending 5-HT neuron systems and their 5-HT receptor subtypes and collateral networks to the forebrain contribute to the etiology of major depression and are targets for treatment. The therapeutic action of serotonin-selective reuptake inhibitors is of proven effectiveness, but the mechanisms underlyin...
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The 5-HT 1A receptor is a subtype of serotonin receptor located in presynaptic and postsynaptic regions. Activation of this receptor has been involved in the mechanism of action of anxiolytic, antidepressant and antipsychotic medications. Serotonin is a monoamine neurotransmitter that interacts with 14 serotonin (5-HT) receptors that can be subdivided into 7 classes [1]. Specifically, the 5-HT ...
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Cognitive control processes may depend on contextual information, sometimes improving performance, but impairing performance if expectancies about forthcoming events induce pre-potent responses. The neurobiological bases of these effects are not understood. Here, we examine context-dependent variations of response control processes using the AX-CPT task with respect to the relevance of the func...
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Although Interferon-alpha (IFN-α) is a powerful drug in treating several viral infections and certain tumors, a considerable amount of neuropsychiatry side-effects such as depression and anxiety are unavoidable consequence. Combination with selective serotonin (5-HT) reuptake inhibitor (SSRI) fluoxetine significantly improved the situation. However, the potential 5-HT1A receptorand 5-HT1B recep...
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Our study investigates the dependence of response monitoring and error detection on genetic influences modulating the serotonergic system. This was done using the event-related potentials (ERPs) after error (Ne/ERN) and correct trials (Nc/CRN). To induce a sufficient amount of errors, a standard flanker task was used. The subjects (N = 94) were genotyped for the functional 5-HT1A C(-1019)G poly...
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ژورنال
عنوان ژورنال: The International Journal of Neuropsychopharmacology
سال: 2004
ISSN: 1461-1457,1469-5111
DOI: 10.1017/s1461145704004663